Aktuelle S3-Leitlinie

Zahnärztliche Chirurgie unter oraler Antikoagulation/Thrombozytenaggregationshemmung

Literatur zu LL Antikoagulantien

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14. Marcumar(R) F: 2015

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32. Iakovou I et al.: Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. JAMA 2005; 293: 2126–30

33. Kaluza GL et al.: Catastrophic outcomes of noncardiac surgery soon after coronary stenting. J Am Coll Cardiol 2000; 35: 1288–94

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37. Douketis JD, Hasselblad V, Ortel TL: Bridging anticoagulation in patients with atrial fibrillation. N Engl J Med 2016; 374: 93–4

38. Bajkin BV, Popovic SL, Selakovic SD: Randomized, prospective trial comparing bridging therapy using low-molecular-weight heparin with maintenance of oral anticoagulation during extraction of teeth. J Oral Maxillofac Surg 2009; 67: 990–5

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41. Kämmerer PW et al.: Comparison of 4 % articaine with epinephrine (1:100,000) and without epinephrine in inferior alveolar block for tooth extraction: double-blind randomized clinical trial of anesthetic efficacy. Oral Surg Oral Med Oral Pathol Oral Radiol 2012; 113: 495–9

42. Kämmerer PW et al.: Comparative clinical evaluation of different epinephrine concentrations in 4 % articaine for dental local infiltration anesthesia. Clin Oral Investig 2014; 18: 415–21

43. Daubländer M et al.: Clinical use of an epinephrine-reduced (1/400,000) articaine solution in short-time dental routine treatments – a multicenter study. Clin Oral Investig 2012; 16: 1289–95

44. Kämmerer PW et al.: Epinephrine-reduced articaine solution (1:400,000) in paediatric dentistry: a multicentre non-interventional clinical trial. Eur Arch Paediatr Dent 2013; 14: 89–95

45. Shabazfar N et al.: Periodontal intraligament injection as alternative to inferior alveolar nerve block – meta-analysis of the literature from 1979 to 2012. Clin Oral Investig 2014; 18: 351–8

46. Kämmerer PW et al.: Clinical efficacy of a computerised device (STA) and a pressure syringe (VarioJect INTRA) for intraligamentary anaesthesia. Eur J Dent Educ 2015; 19: 16–22

47. Cieslik-Bielewska A, Pelc R, Cieslik T: Oral surgery procedures in patients on anticoagulants. Preliminary report. Kardiol Pol 2005; 63: 137–40; discussion 141

48. Blinder D et al.: Dental extractions in patients maintained on continued oral anticoagulant: comparison of local hemostatic modalities. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999; 88: 137–40

49. Bajkin BV et al.: Comparison of efficacy of local hemostatic modalities in anticoagulated patients undergoing tooth extractions. Vojnosanit Pregl 2014; 71: 1097–101

50. Al-Mubarak S et al.: Evaluation of dental extractions, suturing and INR on postoperative bleeding of patients maintained on oral anticoagulant therapy. Br Dent J 2007; 203: E15; discussion 410–1

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52. Rakocz M et al.: Dental extractions in patients with bleeding disorders. The use of fibrin glue. Oral Surg Oral Med Oral Pathol 1993; 75: 280–2

53. Al-Belasy FA, Amer MZ: Hemostatic effect of n-butyl-2-cyanoacrylate (histo- acryl) glue in warfarin-treated patients undergoing oral surgery. J Oral Maxillofac Surg 2003; 61: 1405–9

54. Ramstrom G et al.: Prevention of postsurgical bleeding in oral surgery using tranexamic acid without dose modification of oral anticoagulants. J Oral Maxillofac Surg 1993; 51: 1211–6

55. Soares EC et al.: Postoperative hemostatic efficacy of gauze soaked in tranexamic acid, fibrin sponge, and dry gauze compression following dental extractions in anticoagulated patients with cardiovascular disease: a prospective, randomized study. Oral Maxillofac Surg 2014

56. Halfpenny W, Fraser JS, Adlam DM: Comparison of 2 haemostatic agents for the prevention of postextractional hemorrhage in patients on anticoagulants. Oral Surg Oral Med Oral Pathol 2001; 92: 257–9

57. Carter G et al.: Tranexamic acid mouthwash versus autologous fibrin glue in patients taking warfarin undergoing dental extractions: a randomized prospective clinical study. J Oral Maxillofac Surg, 2003; 61: p 1432–5

58. Devani P, Lavery KM, Howell CJT: Dental extractions in patients on warfarin: Is alteration of anticoagulant regime necessary? Br Dent J 1998; 36: 107–11

59. Blinder D et al.: Dental extractions in patients maintained on oral anticoagulant therapy: comparison of INR value with occurrence of postoperative bleeding. Int J Oral Maxillofac Surg 2001; 30: 518–21

60. Sindet-Pedersen S et al.: Hemostatic effect of tranexamic acid mouthwash in anticoagulant-treated patients undergoing oral surgery. N Engl J Med 1989; 320: 840–3

61. Carter G et al.: Tranexamic acid mouthwash versus autologous fibrin glue in patients taking warfarin undergoing dental extractions: a randomized prospective clinical study. J Oral Maxillofac Surg 2003; 61: 1432–5

62. Carter G, Goss A: Tranexamic acid mouthwash – a prospective randomized study of a 2-day regimen vs 5-day regimen to prevent postoperative bleeding in anticoagulated patients requiring dental extractions. Int J Oral Maxillofac Surg 2003; 32: 504–7

63. Meek IL et al.: Interference of NSAIDs with the thrombocyte inhibitory effect of aspirin: a placebo-controlled, ex vivo, serial placebo-controlled serial crossover study. Eur J Clin Pharmacol 2013; 69: 365–71

64. Yokoyama H et al.: Influence of non-steroidal anti-inflammatory drugs on antiplatelet effect of aspirin. J Clin Pharm Ther 2013; 38: 12–5

65. Cronberg S, Wallmark E, Soderberg I: Effecton platelet aggregation of oral administration of 10 non-steroidal analgesics to humans. Scand J Haematol 1984; 33: 155–9

66. Daniel NG et al.: Antiplatelet drugs: is there a surgical risk? J Can Dent Assoc 2002; 68: 683–7

67. Schafer AI: Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis. J Clin Pharmacol 1995; 35: 209–19

68. Leese PT et al.: Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: a randomized, controlled trial. J Clin Pharmacol 2000; 40: 124–32

69. Clemm R, Neukam FW, Rusche B, Bauersachs A, Musazada S, Schmitt CM: Management of anticoagulated patients in implant therapy: a clinical comparative study. Clin Oral Impl Res 2016; 27: 1274–82

70. Arzneimittelbrief 47, 2013, S. 67

71 Arzneimittelbrief 44, 2013, S. 66–68


Christian Berger (BDIZ EDI)
Matthias Burwinkel (DGI)
Harald Darius (DGK)
Monika Daubländer (IAZA)
Michael Frank (BZÄK, KZBV)
Ti-Sun Kim (DG PARO)
Paulus Kirchhof (DGK)
Jonas Lorenz (DGÄZ)
Armin Mainz (DEGAM)
Norbert Mrochen (BDO)
Emeka Nkenke (AGKi)
Robert Sader (DGÄZ)
Christoph Schindler (AKZ)
Martin Ullner (BDO)
Hans-Otto Wagner (DEGAM)
Thomas Wolf (FVDZ)

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