Fortbildung Parodontologie

Allgemeine Gesundheit und Parodontitis

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Wie werden die systemischen Erkrankungen Atherosklerose, Diabetes mellitus und Rheumatoide Arthritis von lokalen Entzündungserkrankungen wie der Parodontitis beeinflusst? Foto: Fotolia-yodiyim/nerthuz/psdesign1

Literaturverzeichnis

Bahekar, A. A., Singh, S., Saha, S., Molnar, J. & Arora, R. (2007) The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis. Am Heart J 154, 830-837. doi:10.1016/j.ahj.2007.06.037.

Bartruff, J. B., Yukna, R. A. & Layman, D. L. (2005) Outer membrane vesicles from Porphyromonas gingivalis affect the growth and function of cultured human gingival fibroblasts and umbilical vein endothelial cells. J Periodontol 76, 972-979. doi:10.1902/jop.2005.76.6.972.

Bicker, K. L. & Thompson, P. R. (2013) The protein arginine deiminases: Structure, function, inhibition, and disease. Biopolymers 99, 155-163. doi:10.1002/bip.22127.

Bochenek, G., Hasler, R., El Mokhtari, N. E., Konig, I. R., Loos, B. G., Jepsen, S., Rosenstiel, P., Schreiber, S. & Schaefer, A. S. (2013) The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10. Hum Mol Genet 22, 4516-4527. doi:10.1093/hmg/ddt299.

Borgnakke, W. S. (2014) Hyperglycemia/Diabetes mellitus and periodontal infection adversely affect each other. In: Periodontal disease and overall health: a clinician`s guide., (eds.) R. Genco & R. C. Williams, 2nd  Edition edition, pp. 99-122. Professional Audience Communications, Inc.., Pennsylvania, USA.

Borgnakke, W. S., Chapple, I. L., Genco, R. J., Armitage, G., Bartold, P. M., D'Aiuto, F., Eke, P. I., Giannobile, W. V., Kocher, T., Kornman, K. S., Lang, N. P., Madianos, P. N., Murakami, S., Nishimura, F., Offenbacher, S., Preshaw, P. M., Rahman, A. U., Sanz, M., Slots, J., Tonetti, M. S. & Van Dyke, T. E. (2014) The multi-center randomized controlled trial (RCT) published by the journal of the American Medical Association (JAMA) on the effect of periodontal therapy on glycated hemoglobin (HbA1c) has fundamental problems. J Evid Based Dent Pract 14, 127-132. doi:10.1016/j.jebdp.2014.04.017.

Bright, R., Proudman, S. M., Rosenstein, E. D. & Bartold, P. M. (2015) Is there a link between carbamylation and citrullination in periodontal disease and rheumatoid arthritis? Med Hypotheses 84, 570-576. doi:10.1016/j.mehy.2015.03.006.

Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y. & Zychlinsky, A. (2004) Neutrophil extracellular traps kill bacteria. Science 303, 1532-1535. doi:10.1126/science.1092385.

Bugueno, I. M., Khelif, Y., Seelam, N., Morand, D. N., Tenenbaum, H., Davideau, J. L. & Huck, O. (2016) Porphyromonas gingivalis Differentially Modulates Cell Death Profile in Ox-LDL and TNF-alpha Pre-Treated Endothelial Cells. PLoS One 11, e0154590. doi:10.1371/journal.pone.0154590.

Bundesärztekammer (BÄK), K. B. K., Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). (2013) Nationale VersorgungsLeitlinie Therapie des Typ-2-Diabetes – Langfassung, zuletzt geändert: November 2014. Available from: www.dm-therapie.versorgungsleitlinien.de. 1. Auflage. .

Castillo, D. M., Sanchez-Beltran, M. C., Castellanos, J. E., Sanz, I., Mayorga-Fayad, I., Sanz, M. & Lafaurie, G. I. (2011) Detection of specific periodontal microorganisms from bacteraemia samples after periodontal therapy using molecular-based diagnostics. J Clin Periodontol 38, 418-427. doi:10.1111/j.1600-051X.2011.01717.x.

Chapple, I. L., Genco, R. & Working group 2 of joint, E. F. P. A. A. P. w. (2013) Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol 40 Suppl 14, S106-112. doi:10.1111/jcpe.12077.

Christodoulou, C. & Choy, E. H. (2006) Joint inflammation and cytokine inhibition in rheumatoid arthritis. Clin Exp Med 6, 13-19. doi:10.1007/s10238-006-0088-5.

Cooper, P. R., Palmer, L. J. & Chapple, I. L. (2013) Neutrophil extracellular traps as a new paradigm in innate immunity: friend or foe? Periodontol 2000 63, 165-197. doi:10.1111/prd.12025.

Costa, F. O., Miranda Cota, L. O., Pereira Lages, E. J., Soares Dutra Oliveira, A. M., Dutra Oliveira, P. A., Cyrino, R. M., Medeiros Lorentz, T. C., Cortelli, S. C. & Cortelli, J. R. (2013) Progression of periodontitis and tooth loss associated with glycemic control in individuals undergoing periodontal maintenance therapy: a 5-year follow-up study. J Periodontol 84, 595-605. doi:10.1902/jop.2012.120255.

Demoruelle, M. K., Deane, K. D. & Holers, V. M. (2014) When and where does inflammation begin in rheumatoid arthritis? Curr Opin Rheumatol 26, 64-71. doi:10.1097/BOR.0000000000000017.

Deschner, J., Haag, T., Jepsen, S., Kocher, T., Mehnert, H., Meyle, J., Schumm-Draeger, P.-M. & Tschöpe, D. (2011) Diabetes mellitus und Parodontitis. Wechselbeziehung und klinische Implikationen. Ein Konsensuspapier. The Internist 52, 466-477.

Deshpande, R. G., Khan, M. B. & Genco, C. A. (1998) Invasion of aortic and heart endothelial cells by Porphyromonas gingivalis. Infect Immun 66, 5337-5343.

Desvarieux, M., Demmer, R. T., Rundek, T., Boden-Albala, B., Jacobs, D. R., Jr., Sacco, R. L. & Papapanou, P. N. (2005) Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). Circulation 111, 576-582. doi:10.1161/01.CIR.0000154582.37101.15.

Dietrich, T., Jimenez, M., Krall Kaye, E. A., Vokonas, P. S. & Garcia, R. I. (2008) Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. Circulation 117, 1668-1674. doi:10.1161/CIRCULATIONAHA.107.711507.

Dorn, B. R., Dunn, W. A., Jr. & Progulske-Fox, A. (1999) Invasion of human coronary artery cells by periodontal pathogens. Infect Immun 67, 5792-5798.

Dorn, B. R., Dunn, W. A., Jr. & Progulske-Fox, A. (2001) Porphyromonas gingivalis traffics to autophagosomes in human coronary artery endothelial cells. Infect Immun 69, 5698-5708.

Ebersole, J. L. (2003) Humoral immune responses in gingival crevice fluid: local and systemic implications. Periodontol 2000 31, 135-166.

Ebersole, J. L., Cappelli, D., Mathys, E. C., Steffen, M. J., Singer, R. E., Montgomery, M., Mott, G. E. & Novak, M. J. (2002) Periodontitis in humans and non-human primates: oral-systemic linkage inducing acute phase proteins. Ann Periodontol 7, 102-111. doi:10.1902/annals.2002.7.1.102.

Engebretson, S. & Kocher, T. (2013) Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta-analysis. J Clin Periodontol 40 Suppl 14, S153-163. doi:10.1111/jcpe.12084.

Firestein, G. S. (2003) Evolving concepts of rheumatoid arthritis. Nature 423, 356-361. doi:10.1038/nature01661.

Forner, L., Larsen, T., Kilian, M. & Holmstrup, P. (2006) Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation. J Clin Periodontol 33, 401-407. doi:10.1111/j.1600-051X.2006.00924.x.

Fransen, J. & van Riel, P. L. (2005) The Disease Activity Score and the EULAR response criteria. Clin Exp Rheumatol 23, S93-99.

Freire, M. O. & Van Dyke, T. E. (2013) Natural resolution of inflammation. Periodontol 2000 63, 149-164. doi:10.1111/prd.12034.

Friedewald, V. E., Kornman, K. S., Beck, J. D., Genco, R., Goldfine, A., Libby, P., Offenbacher, S., Ridker, P. M., Van Dyke, T. E., Roberts, W. C., American Journal of, C. & Journal of, P. (2009) The American Journal of Cardiology and Journal of Periodontology Editors' Consensus: periodontitis and atherosclerotic cardiovascular disease. Am J Cardiol 104, 59-68. doi:10.1016/j.amjcard.2009.05.002.

Genco, R. J. & Borgnakke, W. S. (2013) Risk factors for periodontal disease. Periodontol 2000 62, 59-94. doi:10.1111/j.1600-0757.2012.00457.x.

Giacona, M. B., Papapanou, P. N., Lamster, I. B., Rong, L. L., D'Agati, V. D., Schmidt, A. M. & Lalla, E. (2004) Porphyromonas gingivalis induces its uptake by human macrophages and promotes foam cell formation in vitro. FEMS Microbiol Lett 241, 95-101. doi:10.1016/j.femsle.2004.10.009.

Gomes, D. A., Pires, J. R., Zuza, E. P., Muscara, M. N., Herrera, B. S., Spolidorio, L. C., Toledo, B. E. & Spolidorio, D. M. (2009) Myeloperoxidase as inflammatory marker of periodontal disease: experimental study in rats. Immunol Invest 38, 117-122. doi:10.1080/08820130802457503.

Grau, A. J., Becher, H., Ziegler, C. M., Lichy, C., Buggle, F., Kaiser, C., Lutz, R., Bultmann, S., Preusch, M. & Dorfer, C. E. (2004) Periodontal disease as a risk factor for ischemic stroke. Stroke 35, 496-501. doi:10.1161/01.STR.0000110789.20526.9D.

Graziani, F., Gennai, S., Solini, A. & Petrini, M. (2017) A systematic review and meta-analysis of epidemiological observational evidence on the effect of periodotitis on diabetes. An update of the EFP-AAP review by Borgnakke et al. (2013). Journal of Clinical Periodontology in print.

Hajishengallis, G. (2014) Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response. Trends Immunol 35, 3-11. doi:10.1016/j.it.2013.09.001.

Hajishengallis, G. (2015) Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol 15, 30-44. doi:10.1038/nri3785.

Han, Y. W. & Wang, X. (2013) Mobile microbiome: oral bacteria in extra-oral infections and inflammation. J Dent Res 92, 485-491. doi:10.1177/0022034513487559.

Holers, V. M. (2013) Autoimmunity to citrullinated proteins and the initiation of rheumatoid arthritis. Curr Opin Immunol 25, 728-735. doi:10.1016/j.coi.2013.09.018.

Humphrey, L. L., Fu, R., Buckley, D. I., Freeman, M. & Helfand, M. (2008) Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis. J Gen Intern Med 23, 2079-2086. doi:10.1007/s11606-008-0787-6.

Iwai, T. (2009) Periodontal bacteremia and various vascular diseases. J Periodontal Res 44, 689-694. doi:10.1111/j.1600-0765.2008.01165.x.

Janket, S. J., Baird, A. E., Chuang, S. K. & Jones, J. A. (2003) Meta-analysis of periodontal disease and risk of coronary heart disease and stroke. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95, 559-569. doi:10.1067/moe.2003.107.

Jepsen, S. & Dommisch, H. (2014) Die parodontale Entzündung. ZM 104, 32-40.

Jepsen, S., Kebschull, M. & Deschner, J. (2011) [Relationship between periodontitis and systemic diseases]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 54, 1089-1096. doi:10.1007/s00103-011-1348-4.

Jepsen, S., Stadlinger, B., Terheyden, H. & Sanz, M. (2015) Science transfer: oral health and general health - the links between periodontitis, atherosclerosis and diabetes. J Clin Periodontol 42, 1071-1073. doi:10.1111/jcpe.12484.

Jimenez, M., Krall, E. A., Garcia, R. I., Vokonas, P. S. & Dietrich, T. (2009) Periodontitis and incidence of cerebrovascular disease in men. Ann Neurol 66, 505-512. doi:10.1002/ana.21742.

Kapellas, K., Maple-Brown, L. J., Jamieson, L. M., Do, L. G., O'Dea, K., Brown, A., Cai, T. Y., Anstey, N. M., Sullivan, D. R., Wang, H., Celermajer, D. S., Slade, G. D. & Skilton, M. R. (2014) Effect of periodontal therapy on arterial structure and function among aboriginal australians: a randomized, controlled trial. Hypertension 64, 702-708. doi:10.1161/HYPERTENSIONAHA.114.03359.

Kassebaum, N. J., Bernabe, E., Dahiya, M., Bhandari, B., Murray, C. J. & Marcenes, W. (2014) Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res 93, 1045-1053. doi:10.1177/0022034514552491.

Kaur, S., Bright, R., Proudman, S. M. & Bartold, P. M. (2014) Does periodontal treatment influence clinical and biochemical measures for rheumatoid arthritis? A systematic review and meta-analysis. Semin Arthritis Rheum 44, 113-122. doi:10.1016/j.semarthrit.2014.04.009.

Kebschull, M., Demmer, R. T. & Papapanou, P. N. (2010) "Gum bug, leave my heart alone!"--epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis. J Dent Res 89, 879-902. doi:10.1177/0022034510375281.

Kebschull, M. & Jepsen, S. (2011) Parodontitis und Atherosklerose. ZM, 28-35.

Khader, Y. S., Dauod, A. S., El-Qaderi, S. S., Alkafajei, A. & Batayha, W. Q. (2006) Periodontal status of diabetics compared with nondiabetics: a meta-analysis. J Diabetes Complications 20, 59-68. doi:10.1016/j.jdiacomp.2005.05.006.

Khlgatian, M., Nassar, H., Chou, H. H., Gibson, F. C., 3rd & Genco, C. A. (2002) Fimbria-dependent activation of cell adhesion molecule expression in Porphyromonas gingivalis-infected endothelial cells. Infect Immun 70, 257-267.

Kinane, D. F., Riggio, M. P., Walker, K. F., MacKenzie, D. & Shearer, B. (2005) Bacteraemia following periodontal procedures. J Clin Periodontol 32, 708-713. doi:10.1111/j.1600-051X.2005.00741.x.

Klareskog, L., Amara, K. & Malmstrom, V. (2014) Adaptive immunity in rheumatoid arthritis: anticitrulline and other antibodies in the pathogenesis of rheumatoid arthritis. Curr Opin Rheumatol 26, 72-79. doi:10.1097/BOR.0000000000000016.

Kozarov, E. (2012) Bacterial invasion of vascular cell types: vascular infectology and atherogenesis. Future Cardiol 8, 123-138. doi:10.2217/fca.11.75.

Kuzmanova, D., Jepsen, S. & H., D. (2017) Wie sind Parodontitis und Diabetes mellitus vergesellschaftet? Zähnarztliche Mitteilungen 107, 1-3.

Lalla, E., Cheng, B., Lal, S., Tucker, S., Greenberg, E., Goland, R. & Lamster, I. B. (2006) Periodontal changes in children and adolescents with diabetes: a case-control study. Diabetes Care 29, 295-299.

Lamster, I. B. & Ahlo, J. K. (2007) Analysis of gingival crevicular fluid as applied to the diagnosis of oral and systemic diseases. Ann N Y Acad Sci 1098, 216-229. doi:10.1196/annals.1384.027.

Leech, M. T. & Bartold, P. M. (2015) The association between rheumatoid arthritis and periodontitis. Best Pract Res Clin Rheumatol 29, 189-201. doi:10.1016/j.berh.2015.03.001.

Lei, L., Li, H., Yan, F., Li, Y. & Xiao, Y. (2011) Porphyromonas gingivalis lipopolysaccharide alters atherosclerotic-related gene expression in oxidized low-density-lipoprotein-induced macrophages and foam cells. J Periodontal Res 46, 427-437. doi:10.1111/j.1600-0765.2011.01356.x.

Leppilahti, J. M., Hernandez-Rios, P. A., Gamonal, J. A., Tervahartiala, T., Brignardello-Petersen, R., Mantyla, P., Sorsa, T. & Hernandez, M. (2014) Matrix metalloproteinases and myeloperoxidase in gingival crevicular fluid provide site-specific diagnostic value for chronic periodontitis. J Clin Periodontol 41, 348-356. doi:10.1111/jcpe.12223.

Lockhart, P. B., Brennan, M. T., Sasser, H. C., Fox, P. C., Paster, B. J. & Bahrani-Mougeot, F. K. (2008) Bacteremia associated with toothbrushing and dental extraction. Circulation 117, 3118-3125. doi:10.1161/CIRCULATIONAHA.107.758524.

Lockhart, P. B., Brennan, M. T., Thornhill, M., Michalowicz, B. S., Noll, J., Bahrani-Mougeot, F. K. & Sasser, H. C. (2009) Poor oral hygiene as a risk factor for infective endocarditis-related bacteremia. J Am Dent Assoc 140, 1238-1244.

Loe, H. (1993) Periodontal disease. The sixth complication of diabetes mellitus. Diabetes Care 16, 329-334.

Looper, K. J., Mustafa, S. S., Zelkowitz, P., Purden, M., Baron, M. & McGill Early Arthritis Research, G. (2012) Work instability and financial loss in early inflammatory arthritis. Int J Rheum Dis 15, 546-553. doi:10.1111/1756-185X.12009.

Loos, B. G. (2005) Systemic markers of inflammation in periodontitis. J Periodontol 76, 2106-2115. doi:10.1902/jop.2005.76.11-S.2106.

Loos, B. G., Craandijk, J., Hoek, F. J., Wertheim-van Dillen, P. M. & van der Velden, U. (2000) Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 71, 1528-1534. doi:10.1902/jop.2000.71.10.1528.

Lundberg, K., Kinloch, A., Fisher, B. A., Wegner, N., Wait, R., Charles, P., Mikuls, T. R. & Venables, P. J. (2008) Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase. Arthritis Rheum 58, 3009-3019. doi:10.1002/art.23936.

Madianos, P. & Koromantzos, P. A. (2017) An update on the evidence on the potential impact of periodontal therapy on diabetes outcomes. Journal of Clinical Periodontology in print.

Marsh, P. D. & Devine, D. A. (2011) How is the development of dental biofilms influenced by the host? J Clin Periodontol 38 Suppl 11, 28-35. doi:10.1111/j.1600-051X.2010.01673.x.

Masson-Bessiere, C., Sebbag, M., Girbal-Neuhauser, E., Nogueira, L., Vincent, C., Senshu, T. & Serre, G. (2001) The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin. J Immunol 166, 4177-4184.

McGraw, W. T., Potempa, J., Farley, D. & Travis, J. (1999) Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun 67, 3248-3256.

Mendes, R. T., Nguyen, D., Stephens, D., Pamuk, F., Fernandes, D., Van Dyke, T. E. & Kantarci, A. (2016) Endothelial Cell Response to Fusobacterium nucleatum. Infect Immun 84, 2141-2148. doi:10.1128/IAI.01305-15.

Meyle, J. & Chapple, I. (2015) Molecular aspects of the pathogenesis of periodontitis. Periodontol 2000 69, 7-17. doi:10.1111/prd.12104.

Mustapha, I. Z., Debrey, S., Oladubu, M. & Ugarte, R. (2007) Markers of systemic bacterial exposure in periodontal disease and cardiovascular disease risk: a systematic review and meta-analysis. J Periodontol 78, 2289-2302. doi:10.1902/jop.2007.070140.

Nesse, W., Abbas, F., van der Ploeg, I., Spijkervet, F. K., Dijkstra, P. U. & Vissink, A. (2008) Periodontal inflamed surface area: quantifying inflammatory burden. J Clin Periodontol 35, 668-673. doi:10.1111/j.1600-051X.2008.01249.x.

Noack, B., Genco, R. J., Trevisan, M., Grossi, S., Zambon, J. J. & De Nardin, E. (2001) Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol 72, 1221-1227. doi:10.1902/jop.2000.72.9.1221.

Nonnenmacher, C., Stelzel, M., Susin, C., Sattler, A. M., Schaefer, J. R., Maisch, B., Mutters, R. & Flores-de-Jacoby, L. (2007) Periodontal microbiota in patients with coronary artery disease measured by real-time polymerase chain reaction: a case-control study. J Periodontol 78, 1724-1730. doi:10.1902/jop.2007.060345.

Orlandi, M., Suvan, J., Petrie, A., Donos, N., Masi, S., Hingorani, A., Deanfield, J. & D'Aiuto, F. (2014) Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis. Atherosclerosis 236, 39-46. doi:10.1016/j.atherosclerosis.2014.06.002.

Parker, H., Albrett, A. M., Kettle, A. J. & Winterbourn, C. C. (2012) Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide. J Leukoc Biol 91, 369-376. doi:10.1189/jlb.0711387.

Polak, D. & Shapira, L. (2017) An udate for the evidence for pathogenic mechanisms that may link periodontitis and diabetes. Journal of Clinical Periodontology in print.

Preshaw, P. M., Alba, A. L., Herrera, D., Jepsen, S., Konstantinidis, A., Makrilakis, K. & Taylor, R. (2012) Periodontitis and diabetes: a two-way relationship. Diabetologia 55, 21-31. doi:10.1007/s00125-011-2342-y.

Qi, M., Miyakawa, H. & Kuramitsu, H. K. (2003) Porphyromonas gingivalis induces murine macrophage foam cell formation. Microb Pathog 35, 259-267.

Renvert, S., Pettersson, T., Ohlsson, O. & Persson, G. R. (2006) Bacterial profile and burden of periodontal infection in subjects with a diagnosis of acute coronary syndrome. J Periodontol 77, 1110-1119. doi:10.1902/jop.2006.050336.

Rosenstein, E. D., Greenwald, R. A., Kushner, L. J. & Weissmann, G. (2004) Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. Inflammation 28, 311-318. doi:10.1007/s10753-004-6641-z.

Roth, G. A., Aumayr, K., Giacona, M. B., Papapanou, P. N., Schmidt, A. M. & Lalla, E. (2009) Porphyromonas gingivalis infection and prothrombotic effects in human aortic smooth muscle cells. Thromb Res 123, 780-784. doi:10.1016/j.thromres.2008.07.008.

Salvi, G. E., Carollo-Bittel, B. & Lang, N. P. (2008) Effects of diabetes mellitus on periodontal and peri-implant conditions: update on associations and risks. J Clin Periodontol 35, 398-409. doi:10.1111/j.1600-051X.2008.01282.x.

Saremi, A., Nelson, R. G., Tulloch-Reid, M., Hanson, R. L., Sievers, M. L., Taylor, G. W., Shlossman, M., Bennett, P. H., Genco, R. & Knowler, W. C. (2005) Periodontal disease and mortality in type 2 diabetes. Diabetes Care 28, 27-32.

Schaefer, A. S., Bochenek, G., Jochens, A., Ellinghaus, D., Dommisch, H., Guzeldemir-Akcakanat, E., Graetz, C., Harks, I., Jockel-Schneider, Y., Weinspach, K., Meyle, J., Eickholz, P., Linden, G. J., Cine, N., Nohutcu, R., Weiss, E., Houri-Haddad, Y., Iraqi, F., Folwaczny, M., Noack, B., Strauch, K., Gieger, C., Waldenberger, M., Peters, A., Wijmenga, C., Yilmaz, E., Lieb, W., Rosenstiel, P., Doerfer, C., Bruckmann, C., Erdmann, J., Konig, I., Jepsen, S., Loos, B. G. & Schreiber, S. (2015) Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis. Circ Cardiovasc Genet 8, 159-167. doi:10.1161/CIRCGENETICS.114.000554.

Schaefer, A. S., Richter, G. M., Groessner-Schreiber, B., Noack, B., Nothnagel, M., El Mokhtari, N. E., Loos, B. G., Jepsen, S. & Schreiber, S. (2009) Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis. PLoS Genet 5, e1000378. doi:10.1371/journal.pgen.1000378.

Shaik-Dasthagirisaheb, Y. B., Huang, N., Baer, M. T. & Gibson, F. C., 3rd (2013) Role of MyD88-dependent and MyD88-independent signaling in Porphyromonas gingivalis-elicited macrophage foam cell formation. Mol Oral Microbiol 28, 28-39. doi:10.1111/omi.12003.

Sharma, P., Dietrich, T., Ferro, C. J., Cockwell, P. & Chapple, I. L. (2016) Association between periodontitis and mortality in stages 3-5 chronic kidney disease: NHANES III and linked mortality study. J Clin Periodontol 43, 104-113. doi:10.1111/jcpe.12502.

Shi, J., Knevel, R., Suwannalai, P., van der Linden, M. P., Janssen, G. M., van Veelen, P. A., Levarht, N. E., van der Helm-van Mil, A. H., Cerami, A., Huizinga, T. W., Toes, R. E. & Trouw, L. A. (2011) Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage. Proc Natl Acad Sci U S A 108, 17372-17377. doi:10.1073/pnas.1114465108.

Shultis, W. A., Weil, E. J., Looker, H. C., Curtis, J. M., Shlossman, M., Genco, R. J., Knowler, W. C. & Nelson, R. G. (2007) Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes. Diabetes Care 30, 306-311. doi:10.2337/dc06-1184.

Simpson, T. C., Weldon, J. C., Worthington, H. V., Needleman, I., Wild, S. H., Moles, D. R., Stevenson, B., Furness, S. & Iheozor-Ejiofor, Z. (2015) Treatment of periodontal disease for glycaemic control in people with diabetes mellitus. Cochrane Database Syst Rev, CD004714. doi:10.1002/14651858.CD004714.pub3.

Spahr, A., Klein, E., Khuseyinova, N., Boeckh, C., Muche, R., Kunze, M., Rothenbacher, D., Pezeshki, G., Hoffmeister, A. & Koenig, W. (2006) Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study. Arch Intern Med 166, 554-559. doi:10.1001/archinte.166.5.554.

Tamayo, T. & Rathmann, W. (2016) Epidemiologie des Diabetes in Deutschland. . In: diabetesDE - Deutscher Gesundheitsbericht Diabetes 2016., (ed.) D. Diabetes-Hilfe, pp. 9-17. Kirchheim & Co GmbH, Mainz,.

Taylor, G. W. & Borgnakke, W. S. (2008) Periodontal disease: associations with diabetes, glycemic control and complications. Oral Dis 14, 191-203. doi:10.1111/j.1601-0825.2008.01442.x.

Taylor, J. J., Preshaw, P. M. & Lalla, E. (2013) A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J Clin Periodontol 40 Suppl 14, S113-134. doi:10.1111/jcpe.12059.

Teeuw, W. J., Slot, D. E., Susanto, H., Gerdes, V. E., Abbas, F., D'Aiuto, F., Kastelein, J. J. & Loos, B. G. (2014) Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis. J Clin Periodontol 41, 70-79. doi:10.1111/jcpe.12171.

Tonetti, M. S. (2009) Periodontitis and risk for atherosclerosis: an update on intervention trials. J Clin Periodontol 36 Suppl 10, 15-19. doi:10.1111/j.1600-051X.2009.01417.x.

Tonetti, M. S., D'Aiuto, F., Nibali, L., Donald, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A. D., Vallance, P. & Deanfield, J. (2007) Treatment of periodontitis and endothelial function. N Engl J Med 356, 911-920. doi:10.1056/NEJMoa063186.

Tonetti, M. S., Van Dyke, T. E. & Working group 1 of the joint, E. F. P. A. A. P. w. (2013) Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol 40 Suppl 14, S24-29. doi:10.1111/jcpe.12089.

Vitkov, L., Klappacher, M., Hannig, M. & Krautgartner, W. D. (2009) Extracellular neutrophil traps in periodontitis. J Periodontal Res 44, 664-672. doi:10.1111/j.1600-0765.2008.01175.x.

Vossenaar, E. R., Zendman, A. J., van Venrooij, W. J. & Pruijn, G. J. (2003) PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease. Bioessays 25, 1106-1118. doi:10.1002/bies.10357.

Wang, Y., Li, M., Stadler, S., Correll, S., Li, P., Wang, D., Hayama, R., Leonelli, L., Han, H., Grigoryev, S. A., Allis, C. D. & Coonrod, S. A. (2009) Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J Cell Biol 184, 205-213. doi:10.1083/jcb.200806072.

Wang, Z., Nicholls, S. J., Rodriguez, E. R., Kummu, O., Horkko, S., Barnard, J., Reynolds, W. F., Topol, E. J., DiDonato, J. A. & Hazen, S. L. (2007) Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nat Med 13, 1176-1184. doi:10.1038/nm1637.

Wegner, N., Lundberg, K., Kinloch, A., Fisher, B., Malmstrom, V., Feldmann, M. & Venables, P. J. (2010a) Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol Rev 233, 34-54. doi:10.1111/j.0105-2896.2009.00850.x.

Wegner, N., Wait, R., Sroka, A., Eick, S., Nguyen, K. A., Lundberg, K., Kinloch, A., Culshaw, S., Potempa, J. & Venables, P. J. (2010b) Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and alpha-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum 62, 2662-2672. doi:10.1002/art.27552.

Willemze, A., Toes, R. E., Huizinga, T. W. & Trouw, L. A. (2012) New biomarkers in rheumatoid arthritis. Neth J Med 70, 392-399.

Yoshie, H., Stadlinger, B., Terheyden, H. & Frankenberger, R. (2013) Illustrierte Beiträge aus der zahnmedizinischen Forschung und Praxis. Quintessenz Verlag, pp. 100.

Zhang, W., Daly, C. G., Mitchell, D. & Curtis, B. (2013) Incidence and magnitude of bacteraemia caused by flossing and by scaling and root planing. J Clin Periodontol 40, 41-52. doi:10.1111/jcpe.12029.

Zimmet, P., Alberti, K. G., Magliano, D. J. & Bennett, P. H. (2016) Diabetes mellitus statistics on prevalence and mortality: facts and fallacies. Nat Rev Endocrinol 12, 616-622. doi:10.1038/nrendo.2016.105.

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